CLOVES syndrome
MONDO:0013038Mondo
Findings
No curated finding names CLOVES syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A syndromic disease characterized by Congenital Lipomatous Overgrowth, progressive, complex and mixed truncal Vascular malformations, Epidermal nevi, and Skeletal anomaly.
Definition from the Mondo Disease Ontology (MONDO:0013038), read 2026-09-29. CC BY 4.0.
- Inheritance
- Typified by somatic mosaicism
- Onset and course
- Congenital onset
HPO, annotations 2026-09-02
Features
47 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Capillary malformationHPOHP:0025104
- 4 of 4 reported patients
- Very frequent (80% to 99% of cases)
- LipomaHPOHP:0012032
- 6 of 6 reported patients
- Lower limb asymmetryHPOHP:0100559
- 5 of 5 reported patients
- Occasional (5% to 29% of cases)
- Venous malformationHPOHP:0012721
- 6 of 6 reported patients
- Frequent (30% to 79% of cases)
- MacrodactylyHPOHP:0004099
- 5 of 6 reported patients
- Frequent (30% to 79% of cases)
- Increased adipose tissueHPOHP:0009126
- Very frequent (80% to 99% of cases)
Show the remaining 35
- Epidermal nevusHPOHP:0010816
- Frequent (30% to 79% of cases)
- Facial asymmetryHPOHP:0000324
- Frequent (30% to 79% of cases)
- HemihypertrophyHPOHP:0001528
- Frequent (30% to 79% of cases)
- Hyperplasia of the maxillaHPOHP:0430028
- Frequent (30% to 79% of cases)
- Ulnar deviation of the handHPOHP:0009487
- Frequent (30% to 79% of cases)
- Abnormal thrombosisHPOHP:0001977
- Occasional (5% to 29% of cases)
Where it sits
Other names
4 names
Resolves to: CLOVES syndrome
- Also called
- CLOVE syndrome, somaticcongenital lipomatous overgrowth-vascular malformation-epidermal nevi-skeletal anomaly syndromecongenital lipomatous overgrowth-vascular malformation-epidermal nevi-spinal anomaly syndromecongenital lipomatous overgrowth, vascular malformations, and epidermal nevi