cleft palate-lateral synechia syndrome
Findings
No curated finding names cleft palate-lateral synechia syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Cleft palate-lateral synechia syndrome (CPLS) is a congenital malformation syndrome characterized by the association of cleft palate and intra-oral lateral synechiae connecting the free borders of the palate and the floor of the mouth. CPLS is presumed to be inherited in an autosomal dominant manner.
Definition from the Mondo Disease Ontology (MONDO:0007337), read 2026-09-29. CC BY 4.0.
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cleft palateHPOHP:0000175
- Very frequent (80% to 99% of cases)
- Abnormality of the voiceHPOHP:0001608
- Frequent (30% to 79% of cases)
- Everted lower lip vermilionHPOHP:0000232
- Frequent (30% to 79% of cases)
- MicrognathiaHPOHP:0000347
- Frequent (30% to 79% of cases)
- Oral synechiaHPOHP:0010285
- Frequent (30% to 79% of cases)
- BlepharophimosisHPOHP:0000581
- Occasional (5% to 29% of cases)
- Full cheeksHPOHP:0000293
- Occasional (5% to 29% of cases)
- Narrow mouthHPOHP:0000160
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: cleft palate-lateral synechia syndrome
- Also called
- CPLS syndrome