classic complement early component deficiency
MONDO:0000015Mondo
Findings
No curated finding names classic complement early component deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) that is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response.
Definition from the Mondo Disease Ontology (MONDO:0000015), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
- Narrower terms (13)
- C1 inhibitor deficiency
- complement component 2 deficiency
- complement component 3 deficiency
- complement component 4a deficiency
- complement component 4b deficiency
- complement component 5 deficiency
- complement component 6 deficiency
- complement component 7 deficiency
- complement component 9 deficiency
- complement component C1r/C1s deficiency
- complement component C1s deficiency
- type I complement component 8 deficiency
- type II complement component 8 deficiency
Other names
1 name
Resolves to: classic complement early component deficiency
- Also called
- genetic deficiency of early component of the classical complement pathway