CLAPO syndrome
MONDO:0013125Mondo
Findings
No curated finding names CLAPO syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
CLAPO syndrome is a newly described syndrome consisting of capillary malformation of the lower lip (C), lymphatic malformation of the face and neck (L), asymmetry of face and limbs (A) and partial or generalized overgrowth (O).
Definition from the Mondo Disease Ontology (MONDO:0013125), read 2026-09-29. CC BY 4.0.
- Inheritance
- Typified by somatic mosaicism
HPO, annotations 2026-09-02
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Capillary hemangiomaHPOHP:0005306
- Obligate (100% of cases)
- Capillary malformation of the lipHPOHP:0031487
- 13 of 13 reported patients
- Obligate (100% of cases)
- HemihypertrophyHPOHP:0001528
- Very frequent (80% to 99% of cases)
- LymphangiomaHPOHP:0100764
- Very frequent (80% to 99% of cases)
- Nevus flammeusHPOHP:0001052
- Very frequent (80% to 99% of cases)
- OvergrowthHPOHP:0001548
- Very frequent (80% to 99% of cases)
Show the remaining 7
- MacrodactylyHPOHP:0004099
- Frequent (30% to 79% of cases)
- Varicose veinsHPOHP:0002619
- Frequent (30% to 79% of cases)
- Venous malformationHPOHP:0012721
- Frequent (30% to 79% of cases)
- Narrow chestHPOHP:0000774
- Occasional (5% to 29% of cases)
- Pectus excavatumHPOHP:0000767
- Occasional (5% to 29% of cases)
- Tall statureHPOHP:0000098
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: CLAPO syndrome
- Also called
- CLAPO syndrome, somatic