chronic recurrent multifocal osteomyelitis
Findings
No curated finding names chronic recurrent multifocal osteomyelitis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Chronic non bacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.
Definition from the Mondo Disease Ontology (MONDO:0009813), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Bone painHPOHP:0002653
- Very frequent (80% to 99% of cases)
- HyperostosisHPOHP:0100774
- Very frequent (80% to 99% of cases)
- OsteomyelitisHPOHP:0002754
- Very frequent (80% to 99% of cases)
- Abnormal epiphysis morphologyHPOHP:0005930
- Frequent (30% to 79% of cases)
- Abnormal metaphysis morphologyHPOHP:0000944
- Frequent (30% to 79% of cases)
- Abnormal vertebral morphologyHPOHP:0003468
- Frequent (30% to 79% of cases)
- ArthritisHPO
Show the remaining 15
- OsteolysisHPOHP:0002797
- Frequent (30% to 79% of cases)
- Poor appetiteHPOHP:0004396
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Abnormal sacroiliac joint morphologyHPOHP:0100781
- Occasional (5% to 29% of cases)
- AcneHPOHP:0001061
- Occasional (5% to 29% of cases)
- AnemiaHPOHP:0001903
- Occasional (5% to 29% of cases)
Where it sits
Other names
6 names
Resolves to: chronic recurrent multifocal osteomyelitis
- Also called
- chronic multifocal osteomyelitischronic recurrent multifocal osteomyelitis (disease)CNO/CRMOCRMONBOnon-bacterial osteomyelitis