chronic myeloid leukemia
Findings
No curated finding names chronic myeloid leukemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.
Definition from the Mondo Disease Ontology (MONDO:0011996), read 2026-09-29. CC BY 4.0.
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Myeloproliferative disorderHPOHP:0005547
- Obligate (100% of cases)
- Abnormal basophil morphologyHPOHP:0001912
- Frequent (30% to 79% of cases)
- Abnormal granulocyte morphologyHPOHP:0001911
- Frequent (30% to 79% of cases)
- Abnormality of blood and blood-forming tissuesHPOHP:0001871
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- Increased total leukocyte count
Where it sits
Other names
17 names
Resolves to: chronic myeloid leukemia
- Also called
- BCR-ABL Positive chronic myelogenous leukaemiaBCR-ABL Positive chronic myelogenous leukemiachronic granulocytic leukemiachronic myelocytic leukaemiachronic myelocytic leukemiachronic myelogenous leukaemia (CML)chronic myelogenous leukemiachronic myelogenous leukemia (CML)chronic myelogenous leukemia, BCR-ABL1 Positivechronic myelogenous leukemiasCMLCML - chronic myelogenous leukaemiaCML - chronic myelogenous leukemiahematopoeitic - chronic myelocytic leukaemia (CML)hematopoeitic - chronic myelocytic leukemia (CML)