chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation
Findings
No curated finding names chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) expressing somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes. The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell. The presence of somatic hypermutations of IGH genes occurs in approximately 50% of CLL/SLL cases and implies a postgerminal center, memory origin. Patients with this variant of CLL/SLL have a favorable prognosis, with a reported median survival of more than 24 years.
Definition from the Mondo Disease Ontology (MONDO:0004152), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
3 names
Resolves to: chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation
- Also called
- CLL/SLL with IGVH SHMpostgerminal center chronic lymphocytic leukemia/small lymphocytic lymphomapostgerminal centre chronic lymphocytic leukemia/small lymphocytic lymphoma