chronic beryllium disease
Findings
No curated finding names chronic beryllium disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Chronic beryllium disease (CBD) is a granulomatous, interstitial lung disease that occurs in individuals who develop beryllium sensitization (BeS), a cell-mediated immune response to environmental and occupational beryllium exposure. BeS precedes the lung disease that may present with chronic dry cough, fatigue, weight loss, chest pain, and increasing dyspnea.
Definition from the Mondo Disease Ontology (MONDO:0015274), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal respiratory system physiologyHPOHP:0002795
- Very frequent (80% to 99% of cases)
- Hypersensitivity pneumonitisHPOHP:0006516
- Very frequent (80% to 99% of cases)
- Immunologic hypersensitivityHPOHP:0100326
- Very frequent (80% to 99% of cases)
- Abnormal CD4+ T cell subset proportionHPOHP:0031392
- Frequent (30% to 79% of cases)
- Abnormal tracheobronchial morphologyHPOHP:0005607
- Frequent (30% to 79% of cases)
- Abnormality on pulmonary function testingHPOHP:0030878
- Frequent (30% to 79% of cases)
Show the remaining 7
- Reduced FEV1/FVC ratioHPOHP:0030877
- Frequent (30% to 79% of cases)
- Respiratory insufficiencyHPOHP:0002093
- Frequent (30% to 79% of cases)
- Reticulonodular pattern on pulmonary HRCTHPOHP:0025393
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Mediastinal lymphadenopathyHPOHP:0100721
- Occasional (5% to 29% of cases)
- Pulmonary fibrosisHPOHP:0002206
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: chronic beryllium disease
- Also called
- Berylliosischronic berylliosischronic beryllium lung disease