childhood disintegrative disorder
Findings
No curated finding names childhood disintegrative disorder yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare pervasive developmental disorder with a disease onset before the age of three and characterized by a dramatic loss of behavioral and developmental functioning after atleast two years of normal development. Manifestations of the disease include loss of speech, incontinence, communication and social interaction problems, stereotypical autistic behaviors and dementia.
Definition from the Mondo Disease Ontology (MONDO:0015681), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal emotional stateHPOHP:0100851
- Very frequent (80% to 99% of cases)
- Autistic behaviorHPOHP:0000729
- Very frequent (80% to 99% of cases)
- Mental deteriorationHPOHP:0001268
- Very frequent (80% to 99% of cases)
- Progressive language deteriorationHPOHP:0007064
- Very frequent (80% to 99% of cases)
- Absent speechHPOHP:0001344
- Frequent (30% to 79% of cases)
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- Bowel incontinence
Show the remaining 4
- Developmental regressionHPOHP:0002376
- Occasional (5% to 29% of cases)
- Motor deteriorationHPOHP:0002333
- Occasional (5% to 29% of cases)
- Severe intellectual disabilityHPOHP:0010864
- Occasional (5% to 29% of cases)
- SeizureHPOHP:0001250
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: childhood disintegrative disorder
- Also called
- childhood disintegrative diseasedementia infantilisdisintegrative psychosisheller syndrome