childhood apraxia of speech
MONDO:0011184Mondo
Findings
No curated finding names childhood apraxia of speech yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal speech patternHPOHP:0002167
- Very frequent (80% to 99% of cases)
- Delayed speech and language developmentHPOHP:0000750
- Very frequent (80% to 99% of cases)
- Abnormal prosodyHPOHP:0031434
- Frequent (30% to 79% of cases)
- Deficit in grammarHPOHP:0006977
- Frequent (30% to 79% of cases)
- DysarthriaHPOHP:0001260
- Frequent (30% to 79% of cases)
- Expressive language delayHPOHP:0002474
- Frequent (30% to 79% of cases)
- Incomprehensible speechHPOHP:0002546
- Frequent (30% to 79% of cases)
- Poor fine motor coordinationHPOHP:0007010
- Frequent (30% to 79% of cases)
- Poor speechHPOHP:0002465
- Frequent (30% to 79% of cases)
- Receptive language delayHPOHP:0010863
- Frequent (30% to 79% of cases)
- Specific learning disabilityHPOHP:0001328
- Frequent (30% to 79% of cases)
- Speech apraxiaHPOHP:0011098
- Frequent (30% to 79% of cases)
Show the remaining 13
- Abnormal caudate nucleus morphologyHPOHP:0002339
- Occasional (5% to 29% of cases)
- Caudate atrophyHPOHP:0002340
- Occasional (5% to 29% of cases)
- Delayed early-childhood social milestone developmentHPOHP:0012434
- Occasional (5% to 29% of cases)
- DroolingHPOHP:0002307
- Occasional (5% to 29% of cases)
- Feeding difficultiesHPOHP:0011968
- Occasional (5% to 29% of cases)
- Poor gross motor coordinationHPOHP:0007015
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FOXP2HGNC:13875
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2022
- Strong · G2P · Autosomal dominant · 2015
- Strong · PanelApp Australia · Autosomal dominant · 2025
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
Other names
4 names
Resolves to: childhood apraxia of speech
- Also called
- CASdevelopmental verbal dyspraxiaspeech and language disorder with orofacial dyspraxiaspeech-language disorder type 1