centrifugal lipodystrophy
Findings
No curated finding names centrifugal lipodystrophy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Centrifugal lipodystrophy is a rare, acquired, localized lipodistrophy characterized by single or, occasionally, multiple, centrifugally progressive, asymptomatic to sometimes mildly tender, hypopigmented, lipoatrophic skin depressions with weakly erymatheous inflammatory borders, typically associated with regional ipsilateral lymph nodes swelling. Lesions typically occur on lower trunk (in particular groin and abdomen region), followed by upper trunk (axilla and neighboring regions) and, rarely, neck and head. It is usually not associated with systemic disease and is typically self-resolving.
Definition from the Mondo Disease Ontology (MONDO:0019552), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- LipoatrophyHPOHP:0100578
- Obligate (100% of cases)
- Reduced subcutaneous adipose tissueHPOHP:0003758
- Very frequent (80% to 99% of cases)
- Absence of subcutaneous fatHPOHP:0007485
- Frequent (30% to 79% of cases)
- Abnormal thorax morphologyHPOHP:0000765
- Occasional (5% to 29% of cases)
- ErythemaHPOHP:0010783
- Occasional (5% to 29% of cases)
- Inflammatory abnormality of the skinHPOHP:0011123
- Occasional (5% to 29% of cases)
- Lymphadenitis
Where it sits
- A kind of
Other names
1 name
Resolves to: centrifugal lipodystrophy
- Also called
- lipodystrophia centrifugalis abdominalis infantilis