catecholaminergic polymorphic ventricular tachycardia 4
Findings
No curated finding names catecholaminergic polymorphic ventricular tachycardia 4 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any catecholaminergic polymorphic ventricular tachycardia in which the cause of the disease is a mutation in the CALM1 gene.
Definition from the Mondo Disease Ontology (MONDO:0013966), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Juvenile onset · Childhood onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Premature ventricular contractionHPOHP:0006682
- 1 of 1 reported patient
- SyncopeHPOHP:0001279
- 13 of 13 reported patients
- Sudden cardiac deathHPOHP:0001645
- 2 of 13 reported patients
- Ventricular tachycardiaHPOHP:0004756
- 2 of 13 reported patients
- Cardiac arrestHPOHP:0001695
- 1 of 13 reported patients
- Ventricular fibrillationHPOHP:0001663
- 1 of 13 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CALM1HGNC:1442
- Strong · Genomics England PanelApp · Autosomal dominant · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2017
- Moderate · G2P · Autosomal dominant · 2024
Where it sits
Other names
4 names
Resolves to: catecholaminergic polymorphic ventricular tachycardia 4
- Also called
- CALM1 catecholaminergic polymorphic ventricular tachycardiacatecholaminergic polymorphic ventricular tachycardia caused by mutation in CALM1catecholaminergic polymorphic ventricular tachycardia type 4ventricular tachycardia, catecholaminergic polymorphic, type 4