Castleman disease
MONDO:0015564Mondo
Findings
No curated finding names Castleman disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.
Definition from the Mondo Disease Ontology (MONDO:0015564), read 2026-09-29. CC BY 4.0.
Features
29 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- LymphadenopathyHPOHP:0002716
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- Constitutional symptomHPOHP:0025142
- Frequent (30% to 79% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Frequent (30% to 79% of cases)
- Elevated erythrocyte sedimentation rateHPOHP:0003565
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Follicular hyperplasiaHPOHP:0002729
- Frequent (30% to 79% of cases)
- Increased circulating interleukin 6 concentrationHPOHP:0030783
- Frequent (30% to 79% of cases)
- Mediastinal lymphadenopathyHPOHP:0100721
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Abdominal distentionHPOHP:0003270
- Occasional (5% to 29% of cases)
Show the remaining 17
- Abdominal massHPOHP:0031500
- Occasional (5% to 29% of cases)
- Abnormality of the gastrointestinal tractHPOHP:0011024
- Occasional (5% to 29% of cases)
- CoughHPOHP:0012735
- Occasional (5% to 29% of cases)
- Decreased mean corpuscular volumeHPOHP:0025066
- Occasional (5% to 29% of cases)
- Flank painHPOHP:0030157
- Occasional (5% to 29% of cases)
- Generalized lymphadenopathyHPOHP:0008940
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
10 names
Resolves to: Castleman disease
- Also called
- AFLHangiofollicular ganglionic hyperplasiaangiofollicular lymph hyperplasiaangiofollicular lymph node hyperplasiaangiofollicular lymphoid hyperplasiaCastleman's diseaseCastleman's tumorCastleman's tumourgiant lymph node hyperplasiaGLNH