Carney complex
MONDO:0015285Mondo
Findings
No curated finding names Carney complex yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Carney complex (CNC) is characterized by spotty skin pigmentation, endocrine overactivity and myxomas.
Definition from the Mondo Disease Ontology (MONDO:0015285), read 2026-09-29. CC BY 4.0.
Features
64 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Pigmented micronodular adrenocortical diseaseHPOHP:0001580
- Very frequent (80% to 99% of cases)
- Atypical nevi in non-sun exposed areasHPOHP:0001074
- Frequent (30% to 79% of cases)
- Blue nevusHPOHP:0100814
- Frequent (30% to 79% of cases)
- Cardiac myxomaHPOHP:0011672
- Frequent (30% to 79% of cases)
- Cutaneous myxomaHPOHP:0030428
- Frequent (30% to 79% of cases)
- Elevated circulating growth hormone concentrationHPOHP:0000845
- Frequent (30% to 79% of cases)
- Euthyroid multinodular goiterHPOHP:0000866
- Frequent (30% to 79% of cases)
- Gonadal neoplasmHPOHP:0010785
- Frequent (30% to 79% of cases)
- Increased circulating cortisol levelHPOHP:0003118
- Frequent (30% to 79% of cases)
- Increased circulating insulin-like growth factor 1 concentrationHPOHP:0030269
- Frequent (30% to 79% of cases)
- Increased circulating prolactin concentrationHPOHP:0000870
- Frequent (30% to 79% of cases)
- Multiple cafe-au-lait spotsHPOHP:0007565
- Frequent (30% to 79% of cases)
Show the remaining 52
- Multiple lentiginesHPOHP:0001003
- Frequent (30% to 79% of cases)
- Ovarian cystHPOHP:0000138
- Frequent (30% to 79% of cases)
- Pituitary growth hormone cell adenomaHPOHP:0011760
- Frequent (30% to 79% of cases)
- Sertoli cell neoplasmHPOHP:0100619
- Frequent (30% to 79% of cases)
- Spotty hyperpigmentationHPOHP:0005585
- Frequent (30% to 79% of cases)
- Testicular neoplasmHPOHP:0010788
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- PRKAR1AHGNC:9388
- Supportive · Orphanet · Autosomal dominant · 2021
Where it sits
- A kind of
Other names
8 names
Resolves to: Carney complex
- Also called
- atrial myxoma with lentiginesCarney syndromeCarney's syndromeCNCLAMBlentigines, atrial myxoma, mucocutaneous myoma, blue Nevus syndromeMyxoma-spotty pigmentation-endocrine overactivity syndromenevi, atrial myxoma, skin myxoma, ephelides syndrome