calciphylaxis
Findings
No curated finding names calciphylaxis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs. The lack of blood flow (ischemia) damages healthy tissue and causes itto die (necrosis). The most obvious and frequent symptom of calciphylaxis is damage to the skin, as ulcers can developand become infected easily. Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure.These symptoms are often irreversible, and many individuals with calciphylaxis may not survive more thana few months after they are diagnosed due to infection that spreads throughout the body (sepsis), or organ failure. The exact cause of calciphylaxis is unknown. Treatments may include medications to reduce pain, antibiotics to treat infections, and various approaches to preventing the development or worsening of this condition.
Definition from the Mondo Disease Ontology (MONDO:0017215), read 2026-09-29. CC BY 4.0.
Features
13 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal skin physiologyHPOHP:0011122
- Very frequent (80% to 99% of cases)
- Abnormality of metabolism/homeostasisHPOHP:0001939
- Very frequent (80% to 99% of cases)
- Arterial calcificationHPOHP:0003207
- Very frequent (80% to 99% of cases)
- CellulitisHPOHP:0100658
- Very frequent (80% to 99% of cases)
- Cutis marmorataHPOHP:0000965
- Very frequent (80% to 99% of cases)
- Ectopic ossification
Where it sits
- Narrower terms (2)