Brunner syndrome
Findings
No curated finding names Brunner syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Monoamine oxidase-A deficiency is a very rare recessive X-linked biogenic amine metabolism disorder characterized clinically by mild intellectual deficit, impulsive aggressiveness, and sometimes violent behavior and presenting from childhood.
Definition from the Mondo Disease Ontology (MONDO:0010379), read 2026-09-29. CC BY 4.0.
- Inheritance
- X-linked recessive inheritance
HPO, annotations 2026-09-02
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atypical behaviorHPOHP:0000708
- Very frequent (80% to 99% of cases)
- Cognitive impairmentHPOHP:0100543
- Very frequent (80% to 99% of cases)
- Motor delayHPOHP:0001270
- Occasional (5% to 29% of cases)
- Aggressive behaviorHPOHP:0000718
- AutismHPOHP:0000717
- Intellectual disabilityHPOHP:0001249
- Low frustration toleranceHPOHP:0000744
- Self-injurious behaviorHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MAOAHGNC:6833
- Definitive · ClinGen · X-linked · 2026
- Strong · Labcorp Genetics (formerly Invitae) · X-linked · 2021
- Strong · G2P · X-linked · 2015
- Strong · PanelApp Australia · X-linked · 2025
- Supportive · Orphanet · X-linked · 2021
Where it sits
Other names
3 names
Resolves to: Brunner syndrome
- Also called
- antisocial behavior, X-linked recessiveBrunner syndrome, X-linked recessivemonoamine oxidase A deficiency