Bowen disease of the skin
Findings
No curated finding names Bowen disease of the skin yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A form of squamous cell carcinoma in situ. It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. It affects predominantly white males in their 6-8th decades of life. Exposed and non-exposed skin sites are equally affected. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. On the skin surface, it presents as a single or multiple erythematous, scaly, keratotic patches or plaques. The clinical entity of erythroplasia of Queyrat is regarded as Bowen disease of the penis and it presents as an asymptomatic, red, circumscribed plaque. Morphologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. Complete surgical removal of the lesion may be curative.
Definition from the Mondo Disease Ontology (MONDO:0020761), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
Other names
6 names
Resolves to: Bowen disease of the skin
- Also called
- Bowen DiseaseBowen's disease of the skinBowens DiseaseDisease, BowenDisease, Bowen'sintraepidermal squamous cell carcinoma, Bowen type