bone osteosarcoma
MONDO:0002629Mondo
Findings
No curated finding names bone osteosarcoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs.
Definition from the Mondo Disease Ontology (MONDO:0002629), read 2026-09-29. CC BY 4.0.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal femoral metaphysis morphologyHPOHP:0006489
- Very frequent (80% to 99% of cases)
- OsteolysisHPOHP:0002797
- Very frequent (80% to 99% of cases)
- Abnormal circulating lactate dehydrogenase concentrationHPOHP:0045040
- Frequent (30% to 79% of cases)
- Abnormal metaphysis morphologyHPOHP:0000944
- Frequent (30% to 79% of cases)
- Abnormal tibial metaphysis morphologyHPOHP:0006491
- Frequent (30% to 79% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Frequent (30% to 79% of cases)
- Increased circulating lactate dehydrogenase concentrationHPOHP:0025435
- Frequent (30% to 79% of cases)
- Joint swellingHPOHP:0001386
- Frequent (30% to 79% of cases)
- PainHPOHP:0012531
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Very rare (1% to 4% of cases)
- Pathologic fractureHPOHP:0002756
- Very rare (1% to 4% of cases)
- Weight lossHPOHP:0001824
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: bone osteosarcoma
- Also called
- osteosarcoma of boneosteosarcoma, somaticosteosarcoma, somatic mutation