bleeding disorder, platelet-type, 25
MONDO:0957580Mondo
Findings
No curated finding names bleeding disorder, platelet-type, 25 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Bruising susceptibilityHPOHP:0000978
- 3 of 3 reported patients
- Impaired collagen-induced platelet aggregationHPOHP:0008320
- 3 of 3 reported patients
- Increased mean platelet volumeHPOHP:0011877
- 8 of 8 reported patients
- MenorrhagiaHPOHP:0000132
- 5 of 6 reported patients
- MacrothrombocytopeniaHPOHP:0040185
- 4 of 5 reported patients
- Excessive bleeding from superficial cutsHPOHP:0030138
- 2 of 3 reported patients
- Impaired ADP-induced platelet aggregationHPOHP:0004866
- 2 of 3 reported patients
- Spontaneous, recurrent epistaxisHPOHP:0004406
- 2 of 3 reported patients
- Post-partum hemorrhageHPOHP:0011891
- 1 of 2 reported patients
- ThrombocytopeniaHPOHP:0001873
- 4 of 8 reported patients
- Prolonged bleeding after dental extractionHPOHP:0006298
- 3 of 8 reported patients
- Prolonged bleeding after surgeryHPOHP:0004846
- 1 of 5 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TPM4HGNC:12013
- Strong · PanelApp Australia · Autosomal dominant · 2025