benign recurrent intrahepatic cholestasis
Findings
No curated finding names benign recurrent intrahepatic cholestasis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Benign recurrent intrahepatic cholestasis (BRIC) is a hereditary liver disorder characterized by intermittent episodes of intrahepatic cholestasis, generally without progression to chronic liver damage. BRIC is now believed to belong to a clinical spectrum of intrahepatic cholestatic disorders that ranges from the mild intermittent attacks in BRIC to the severe, chronic and progressive cholestasis seen in progressive familial intrahepatic cholestasis (PFIC).
Definition from the Mondo Disease Ontology (MONDO:0019008), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Acholic stoolsHPOHP:0011985
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- Cholestatic liver diseaseHPOHP:0002611
- Very frequent (80% to 99% of cases)
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- JaundiceHPOHP:0000952
- Very frequent (80% to 99% of cases)
Show the remaining 4
- CirrhosisHPOHP:0001394
- Occasional (5% to 29% of cases)
- Hearing impairmentHPOHP:0000365
- Occasional (5% to 29% of cases)
- Hepatocellular carcinomaHPOHP:0001402
- Occasional (5% to 29% of cases)
- PancreatitisHPOHP:0001733
- Occasional (5% to 29% of cases)
Where it sits
Other names
3 names
Resolves to: benign recurrent intrahepatic cholestasis
- Also called
- BRICcholestasis, benign recurrent intrahepaticSummerskill-Walshe-Tygstrup syndrome