autoimmune primary adrenal insufficiency
MONDO:0100480Mondo
Findings
No curated finding names autoimmune primary adrenal insufficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Diminished production of adrenocortical hormones due to autoimmune destruction of the adrenal glands.
Definition from the Mondo Disease Ontology (MONDO:0100480), read 2026-09-29. CC BY 4.0.
Features
62 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased circulating cortisol levelHPOHP:0008163
- Obligate (100% of cases)
- Primary adrenal insufficiencyHPOHP:0008207
- Obligate (100% of cases)
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- ConstipationHPOHP:0002019
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- Failure to thriveHPOHP:0001508
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Hyperpigmentation of the skinHPOHP:0000953
- Very frequent (80% to 99% of cases)
- HypotensionHPOHP:0002615
- Very frequent (80% to 99% of cases)
- Increased circulating ACTH levelHPOHP:0003154
- Very frequent (80% to 99% of cases)
Show the remaining 50
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
- Nausea and vomitingHPOHP:0002017
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Very frequent (80% to 99% of cases)
- Abnormality of the axillary hairHPOHP:0100134
- Frequent (30% to 79% of cases)
- Abnormality of the pubic hairHPOHP:0100133
- Frequent (30% to 79% of cases)
- Androgen insufficiencyHPOHP:0008226
- Frequent (30% to 79% of cases)
Where it sits
Other names
7 names
Resolves to: autoimmune primary adrenal insufficiency
- Also called
- Addison diseaseAddison's diseaseautoimmune Addison diseaseautoimmune Addison's diseaseautoimmune adrenalitisclassic Addison's diseaseprimary Addison's disease