autoimmune polyendocrinopathy type 3
Findings
No curated finding names autoimmune polyendocrinopathy type 3 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare, endocrine disease characterized by autoimmune thyroid disease associated with at least one other autoimmune disease, such as type I diabetes mellitus, chronic atrophic gastritis, pernicious anemia, vitiligo, alopecia, or myasthenia gravis, but excluding Addison disease.
Definition from the Mondo Disease Ontology (MONDO:0016422), read 2026-09-29. CC BY 4.0.
Features
31 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AutoimmunityHPOHP:0002960
- Obligate (100% of cases)
- Atrophic gastritisHPOHP:0002582
- Frequent (30% to 79% of cases)
- Autoimmune antibody positivityHPOHP:0030057
- Frequent (30% to 79% of cases)
- Celiac diseaseHPOHP:0002608
- Frequent (30% to 79% of cases)
- Graves diseaseHPOHP:0100647
- Frequent (30% to 79% of cases)
- Hashimoto thyroiditisHPOHP:0000872
- Frequent (30% to 79% of cases)
- Macrocytic anemiaHPOHP:0001972
- Frequent (30% to 79% of cases)
- Type I diabetes mellitusHPOHP:0100651
- Frequent (30% to 79% of cases)
- AlopeciaHPOHP:0001596
- Occasional (5% to 29% of cases)
- Anterior pituitary dysgenesisHPOHP:0010625
- Occasional (5% to 29% of cases)
- Biliary cirrhosisHPOHP:0002613
- Occasional (5% to 29% of cases)
- Decreased circulating immunoglobulin concentrationHPOHP:0004313
- Occasional (5% to 29% of cases)
Reported absent (2)
- Primary adrenal insufficiencyHPOHP:0008207
- Recurrent mucocutaneous candidiasisHPOHP:0002728
Show the remaining 19
- Decreased total leukocyte countHPOHP:0001882
- Occasional (5% to 29% of cases)
- VitiligoHPOHP:0001045
- Occasional (5% to 29% of cases)
- Abnormal blistering of the skinHPOHP:0008066
- Very rare (1% to 4% of cases)
- Abnormal pulmonary interstitial morphologyHPOHP:0006530
- Very rare (1% to 4% of cases)
- Antiphospholipid antibody positivityHPOHP:0003613
- Very rare (1% to 4% of cases)
- Aplasia/Hypoplasia of the spleenHPOHP:0010451
- Very rare (1% to 4% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: autoimmune polyendocrinopathy type 3
- Also called
- APS type 3APS3autoimmune polyendocrine syndrome type 3autoimmune polyglandular syndrome type 3