autoimmune polyendocrinopathy type 2
MONDO:0010012Mondo
Findings
No curated finding names autoimmune polyendocrinopathy type 2 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autoimmune polyglandular syndrome of likely polygenic etiology characterized by the presence of primary adrenal insufficiency in association with autoimmune thyroiditis and/or type 1 diabetes mellitus; this condition is not associated with mucocutaneous candidiasis.
Definition from the Mondo Disease Ontology (MONDO:0010012), read 2026-09-29. CC BY 4.0.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the thyroid glandHPOHP:0000820
- Very frequent (80% to 99% of cases)
- Celiac diseaseHPOHP:0002608
- Very frequent (80% to 99% of cases)
- Graves diseaseHPOHP:0100647
- Very frequent (80% to 99% of cases)
- Hashimoto thyroiditisHPOHP:0000872
- Very frequent (80% to 99% of cases)
- Primary adrenal insufficiencyHPOHP:0008207
- Very frequent (80% to 99% of cases)
- Type I diabetes mellitusHPOHP:0100651
- Very frequent (80% to 99% of cases)
- Abnormality of the musculatureHPOHP:0003011
- Frequent (30% to 79% of cases)
- AlopeciaHPOHP:0001596
- Frequent (30% to 79% of cases)
- Anti-steroid 17alpha-hydroxylase antibody positivityHPOHP:0034061
- Frequent (30% to 79% of cases)
- HypogonadismHPOHP:0000135
- Frequent (30% to 79% of cases)
- HypoparathyroidismHPOHP:0000829
- Frequent (30% to 79% of cases)
- Hypopigmented skin patchesHPOHP:0001053
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
7 names
Resolves to: autoimmune polyendocrinopathy type 2
- Also called
- APS type 2APS2autoimmune polyendocrine syndrome type 2Autoimmune Polyendocrine Syndrome Type IIautoimmune polyglandular syndrome type 2autoimmune thyroid disease and/or type 1 diabetes-Addison disease syndromeSchmidt syndrome