autoimmune lymphoproliferative syndrome type 4
MONDO:0013767Mondo
Findings
No curated finding names autoimmune lymphoproliferative syndrome type 4 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
RAS-associated autoimmune leukoproliferative disease (RALD) is a rare genetic disorder characterized by monocytosis, autoimmune cytopenias, lymphoproliferation, hepatosplenomegaly, and hypergammaglobulinemia.
Definition from the Mondo Disease Ontology (MONDO:0013767), read 2026-09-29. CC BY 4.0.
- Inheritance
- Typified by somatic mosaicism
HPO, annotations 2026-09-02
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- KRASHGNC:6407
- Strong · PanelApp Australia · Autosomal dominant · 2025
Where it sits
Other names
7 names
Resolves to: autoimmune lymphoproliferative syndrome type 4
- Also called
- ALPS4autoimmune lymphoproliferative syndrome caused by mutation in NRASNRAS autoimmune lymphoproliferative syndromeRALDRAS-associated autoimmune leukoproliferative diseaseRAS-associated autoimmune leukoproliferative disorderRAS-associated autoimmune lymphoproliferative syndrome type IV, somatic