autoimmune encephalopathy with parasomnia and obstructive sleep apnea
Findings
No curated finding names autoimmune encephalopathy with parasomnia and obstructive sleep apnea yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Autoimmune encephalopathy with parasomnia and obstructive sleep apnea is a rare neurologic disorder characterized by a unique non-REM and REM parasomnia with sleep breathing dysfunction, gait instability and repetitive episodes of respiratory insufficiency, as well as autoantibodies against IgLON5. Patients may present stridor, chorea, limb ataxia, abnormal ocular movements, and bulbar symptoms (i.e. dysphagia, dysarthria, episodic central hypoventilation) with normal brain MRI. Excessive day sleepiness and cognitive deterioration have also been reported.
Definition from the Mondo Disease Ontology (MONDO:0018489), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
2 names
Resolves to: autoimmune encephalopathy with parasomnia and obstructive sleep apnea
- Also called
- anti-IgLON5 diseaseanti-IgLON5 syndrome