attenuated familial adenomatous polyposis
Findings
No curated finding names attenuated familial adenomatous polyposis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Attenuated familial adenomatous polyposis (AFAP) is a mild form of familial adenomatous polyposis characterized by the presence of fewer than 100 adenomatous colonic polyps, a more proximal colonic location, a delayed age of colorectal cancer (CRC) onset and a more limited expression of the extracolonic features.
Definition from the Mondo Disease Ontology (MONDO:0016362), read 2026-09-29. CC BY 4.0.
Features
22 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Colorectal polyposisHPOHP:0200063
- Very frequent (80% to 99% of cases)
- Adenomatous colonic polyposisHPOHP:0005227
- Frequent (30% to 79% of cases)
- Colon cancerHPOHP:0003003
- Frequent (30% to 79% of cases)
- Duodenal polyposisHPOHP:0004783
- Frequent (30% to 79% of cases)
- Large intestinal polyposisHPOHP:0030255
- Frequent (30% to 79% of cases)
- Multiple gastric polypsHPOHP:0004394
- Frequent (30% to 79% of cases)
- Neoplasm of the stomachHPO
Reported absent (1)
- Congenital hypertrophy of retinal pigment epitheliumHPOHP:0007649
Show the remaining 10
- PapillomaHPOHP:0012740
- Occasional (5% to 29% of cases)
- Thyroid adenomaHPOHP:0000854
- Occasional (5% to 29% of cases)
- Uterine leiomyomaHPOHP:0000131
- Occasional (5% to 29% of cases)
- Adrenocortical adenomaHPOHP:0008256
- Very rare (1% to 4% of cases)
- Adrenocortical carcinomaHPOHP:0006744
- Very rare (1% to 4% of cases)
- Breast carcinomaHPOHP:0003002
- Very rare (1% to 4% of cases)
Where it sits
- Narrower terms (1)
Other names
7 names
Resolves to: attenuated familial adenomatous polyposis
- Also called
- AAPCAFAPattenuated adenomatous polyposis coliattenuated familial polyposis coliattenuated FAPhereditary flat adenoma syndromeHFAS