antisynthetase syndrome
MONDO:0019344Mondo
Findings
No curated finding names antisynthetase syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Antisynthetase (AS) syndrome is a clinically heterogeneous form of idiopathic inflammatory myopathy characterized by myositis, arthralgia, Raynaud phenomenon, mechanic hands, interstitial lung disease (ILD), and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS).
Definition from the Mondo Disease Ontology (MONDO:0019344), read 2026-09-29. CC BY 4.0.
Features
44 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal pulmonary interstitial morphologyHPOHP:0006530
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- Chest painHPOHP:0100749
- Very frequent (80% to 99% of cases)
- CoughHPOHP:0012735
- Very frequent (80% to 99% of cases)
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
- MyalgiaHPOHP:0003326
- Very frequent (80% to 99% of cases)
- MyositisHPOHP:0100614
- Very frequent (80% to 99% of cases)
- Pulmonary fibrosisHPOHP:0002206
- Very frequent (80% to 99% of cases)
- Respiratory insufficiencyHPOHP:0002093
- Very frequent (80% to 99% of cases)
- Anti-alanyl-tRNA synthetase antibody positivityHPOHP:0034145
- Frequent (30% to 79% of cases)
- Anti-aminoacyl-tRNA synthetase antibody positivityHPOHP:0034147
- Frequent (30% to 79% of cases)
- Anti-asparaginyl-tRNA synthetase antibody positivityHPOHP:0034151
- Frequent (30% to 79% of cases)
Show the remaining 32
- Anti-cytosolic-5-nucleotidase-1A antibody positivityHPOHP:0034153
- Frequent (30% to 79% of cases)
- Anti-glycyl tRNA-synthetase antibody positivityHPOHP:0034146
- Frequent (30% to 79% of cases)
- Anti-histidyl tRNA synthetase antibody positivityHPOHP:0034152
- Frequent (30% to 79% of cases)
- Anti-isoleucyl tRNA-synthetase antibody positivityHPOHP:0034148
- Frequent (30% to 79% of cases)
- Anti-phenylalanyl tRNA synthetase antibody positivityHPOHP:0034149
- Frequent (30% to 79% of cases)
- Anti-threonyl-tRNA synthetase antibody positivityHPOHP:0034143
Where it sits
Other names
2 names
Resolves to: antisynthetase syndrome
- Also called
- anti-Jo1 syndromeAS syndrome