antiphospholipid syndrome
Findings
No curated finding names antiphospholipid syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A disorder caused by the presence of autoantibodies directed against phospholipids, causing a hypercoaguable state, which may result in blood clots, stroke, heart attack, and in women, significant pregnancy-related complications, including miscarriage and still birth. The syndrome is often associated with other autoimmune disorders, most commonly lupus erythematosus, and infections, including syphilis and Lyme disease.
Definition from the Mondo Disease Ontology (MONDO:8000010), read 2026-09-29. CC BY 4.0.
Features
39 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Intrauterine growth retardationHPOHP:0001511
- Very frequent (80% to 99% of cases)
- Anti-beta 2 glycoprotein I antibody positivityHPOHP:0032376
- Frequent (30% to 79% of cases)
- Anti-beta-2-Glycoprotein I IgG antibody positivityHPOHP:0034156
- Frequent (30% to 79% of cases)
- Anti-beta-2-Glycoprotein I IgM antibody positivityHPOHP:0034157
- Frequent (30% to 79% of cases)
- Anticardiolipin IgG antibody positivityHPOHP:0020136
- Frequent (30% to 79% of cases)
- Anticardiolipin IgM antibody positivityHPOHP:0020137
- Frequent (30% to 79% of cases)
Show the remaining 27
- Ischemic strokeHPOHP:0002140
- Frequent (30% to 79% of cases)
- Livedo racemosaHPOHP:0033260
- Frequent (30% to 79% of cases)
- Livedo reticularisHPOHP:0033505
- Frequent (30% to 79% of cases)
- Lupus anticoagulantHPOHP:0025343
- Frequent (30% to 79% of cases)
- PainHPOHP:0012531
- Frequent (30% to 79% of cases)
- Premature birthHPOHP:0001622
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
3 names
Resolves to: antiphospholipid syndrome
- Also called
- antiphospholipid antibody syndromefamilial lupus anticoagulantHughes syndrome