anti-NMDA receptor encephalitis
Findings
No curated finding names anti-NMDA receptor encephalitis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor.
Definition from the Mondo Disease Ontology (MONDO:0021081), read 2026-09-29. CC BY 4.0.
Features
53 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-NMDA receptor antibody positivityHPOHP:0032264
- Very frequent (80% to 99% of cases)
- Atypical behaviorHPOHP:0000708
- Very frequent (80% to 99% of cases)
- ConfusionHPOHP:0001289
- Very frequent (80% to 99% of cases)
- CSF anti-NMDA receptor antibody positivityHPOHP:0032266
- Very frequent (80% to 99% of cases)
- CSF pleocytosisHPOHP:0012229
- Very frequent (80% to 99% of cases)
- Memory impairmentHPOHP:0002354
- Very frequent (80% to 99% of cases)
Show the remaining 41
- DyskinesiaHPOHP:0100660
- Frequent (30% to 79% of cases)
- EEG with temporal sharp slow wavesHPOHP:0011289
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HallucinationsHPOHP:0000738
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- InsomniaHPOHP:0100785
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: anti-NMDA receptor encephalitis
- Also called
- limbic encephalitis with N-methyl-D-aspartate receptor antibodieslimbic encephalitis with NMDA receptor antibodies