anaplastic astrocytoma
Findings
No curated finding names anaplastic astrocytoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord.
Definition from the Mondo Disease Ontology (MONDO:0016684), read 2026-09-29. CC BY 4.0.
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- BRAFHGNC:1097
- Limited · Ambry Genetics · Autosomal dominant · 2018
Where it sits
Other names
6 names
Resolves to: anaplastic astrocytoma
- Also called
- astrocytoma, anaplastic, malignantgrade III astrocytic neoplasmgrade III astrocytic tumorgrade III astrocytic tumourgrade III astrocytomamalignant astrocytoma