amyotrophic lateral sclerosis type 10
Findings
No curated finding names amyotrophic lateral sclerosis type 10 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the TARDBP gene.
Definition from the Mondo Disease Ontology (MONDO:0012790), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Late onset
HPO, annotations 2026-09-02
Features
1 feature
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Amyotrophic lateral sclerosisHPOHP:0007354
- 3 of 3 reported patients · Late onset
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TARDBPHGNC:11571
- Definitive · Ambry Genetics · Autosomal dominant · 2018
- Definitive · ClinGen · Autosomal dominant · 2021
- Strong · Genomics England PanelApp · Autosomal dominant · 2021
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
Where it sits
Other names
5 names
Resolves to: amyotrophic lateral sclerosis type 10
- Also called
- ALS10amyotrophic lateral sclerosis 10, with or without FTDamyotrophic lateral sclerosis caused by mutation in TARDBPfrontotemporal lobar degeneration, TARDBP-relatedTARDBP amyotrophic lateral sclerosis