amyotrophic lateral sclerosis 28
MONDO:0957538Mondo
Findings
No curated finding names amyotrophic lateral sclerosis 28 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Middle age onset · Late young adult onset
HPO, annotations 2026-09-02
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Lower limb muscle weaknessHPOHP:0007340
- 8 of 10 reported patients
- Diminished deep tendon reflexHPOHP:0001315
- 5 of 10 reported patients
- Skeletal muscle atrophyHPOHP:0003202
- 5 of 10 reported patients
- Difficulty climbing stairsHPOHP:0003551
- 4 of 10 reported patients
- DysarthriaHPOHP:0001260
- 3 of 10 reported patients
- DysphagiaHPOHP:0002015
- 3 of 10 reported patients
- Fiber type groupingHPOHP:0033685
- 3 of 10 reported patients
- FasciculationsHPOHP:0002380
- 2 of 10 reported patients
- Gait disturbanceHPOHP:0001288
- 2 of 10 reported patients
- Upper limb muscle weaknessHPOHP:0003484
- 2 of 10 reported patients
- Babinski signHPOHP:0003487
- 1 of 10 reported patients
- Chaddock reflexHPOHP:0010875
- 1 of 10 reported patients
Show the remaining 5
- Difficulty standingHPOHP:0003698
- 1 of 10 reported patients
- Muscle weaknessHPOHP:0001324
- 1 of 10 reported patients
- MyalgiaHPOHP:0003326
- 1 of 10 reported patients
- Respiratory failureHPOHP:0002878
- 1 of 10 reported patients
- Rimmed vacuolesHPOHP:0003805
- 1 of 10 reported patients