amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
MONDO:0030885Mondo
Findings
No curated finding names amyotrophic lateral sclerosis 26 with or without frontotemporal dementia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Late onset · Middle age onset · Young adult onset
HPO, annotations 2026-09-02
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Lewy bodiesHPOHP:0100315
- 5 of 5 reported patients
- Amyotrophic lateral sclerosisHPOHP:0007354
- 8 of 9 reported patients
- Frontotemporal dementiaHPOHP:0002145
- 5 of 9 reported patients
- AphasiaHPOHP:0002381
- 3 of 9 reported patients
- Bulbar palsyHPOHP:0001283
- 3 of 9 reported patients
- Limb muscle weaknessHPOHP:0003690
- 2 of 9 reported patients
- Memory impairmentHPOHP:0002354
- 1 of 9 reported patients
- Personality changesHPOHP:0000751
- 1 of 9 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TIA1HGNC:11802
- Moderate · PanelApp Australia · Semidominant · 2025
- Limited · ClinGen · Autosomal dominant · 2022
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2021
Where it sits
Other names
1 name
Resolves to: amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
- Also called
- ALS26