alobar holoprosencephaly
MONDO:0019757Mondo
Findings
No curated finding names alobar holoprosencephaly yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Alobar holoprosencephaly is the most severe classical form of holoprosencephaly (HPE) characterized by a single brain ventricle and no interhemispheric fissure.
Definition from the Mondo Disease Ontology (MONDO:0019757), read 2026-09-29. CC BY 4.0.
Features
72 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the eyeHPOHP:0000478
- Very frequent (80% to 99% of cases)
- Failure to thriveHPOHP:0001508
- Very frequent (80% to 99% of cases)
- Feeding difficultiesHPOHP:0011968
- Very frequent (80% to 99% of cases)
- Growth delayHPOHP:0001510
- Very frequent (80% to 99% of cases)
- HypotelorismHPOHP:0000601
- Very frequent (80% to 99% of cases)
- Poor suckHPOHP:0002033
- Very frequent (80% to 99% of cases)
- Short statureHPOHP:0004322
- Very frequent (80% to 99% of cases)
- Abnormal brainstem morphologyHPOHP:0002363
- Frequent (30% to 79% of cases)
- Abnormal central motor functionHPOHP:0011442
- Frequent (30% to 79% of cases)
- Abnormal hypothalamus physiologyHPOHP:0012285
- Frequent (30% to 79% of cases)
- Abnormal morphology of the olfactory bulbHPOHP:0040327
- Frequent (30% to 79% of cases)
- Abnormal pattern of respirationHPOHP:0002793
- Frequent (30% to 79% of cases)
Show the remaining 60
- Abnormality of the autonomic nervous systemHPOHP:0002270
- Frequent (30% to 79% of cases)
- Absent speechHPOHP:0001344
- Frequent (30% to 79% of cases)
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- ApathyHPOHP:0000741
- Frequent (30% to 79% of cases)
- Aplasia of the falx cerebriHPOHP:0010654
- Frequent (30% to 79% of cases)
- Aspiration pneumoniaHPOHP:0011951
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
- Narrower terms (2)