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Reference

Evidence

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Outcomes
Proteins
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Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

Disease

ALK-positive large B-cell lymphoma

MONDO:0018225Mondo

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Findings

No curated finding names ALK-positive large B-cell lymphoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma is a very rare variant of diffuse large B-cell lymphoma (DLBCL) mainly affecting middle-aged immunocompetent men and characterized by a consistent primary involvement of lymph nodes (mainly in the cervical and mediastinum lymph nodes) and with infrequent extra nodal involvement of the bone marrow and other extra-nodal sites (head and neck region, liver, spleen, and gastrointestinal tract). It has an aggressive disease course, and is associated with a poor prognosis.

Definition from the Mondo Disease Ontology (MONDO:0018225), read 2026-09-29. CC BY 4.0.

Where it sits

A kind of: diffuse large B-cell lymphoma

Other names

5 names

Resolves to: ALK-positive large B-cell lymphoma

Also called: ALK-DLBCLALK+ large B-cell lymphomaALK+ LBCLdiffuse large B-cell lymphoma with expression of full-length ALKdiffuse large B-cell lymphoma with expression of full-length anaplastic lymphoma kinase