ALECT2 amyloidosis
Findings
No curated finding names ALECT2 amyloidosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare, systemic amyloidosis characterized by slowly progressive renal disease presenting with proteinuria, hypertension and decreased glomerular filtration rate leading to progressive renal failure. Histology reveals amyloid deposits of leukocyte chemotactic factor-2 protein in the renal cortical interstitium, tubular basement membranes, glomeruli and the vessel walls. Extra-renal deposits can be seen in the liver, lungs, spleen and adrenal glands.
Definition from the Mondo Disease Ontology (MONDO:0018588), read 2026-09-29. CC BY 4.0.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Hepatic amyloidosisHPOHP:0012280
- Very frequent (80% to 99% of cases)
- Renal amyloidosisHPOHP:0001917
- Very frequent (80% to 99% of cases)
- Elevated circulating creatinine concentrationHPOHP:0003259
- Frequent (30% to 79% of cases)
- HypertensionHPOHP:0000822
- Frequent (30% to 79% of cases)
- ProteinuriaHPOHP:0000093
- Frequent (30% to 79% of cases)
- Pulmonary amyloidosisHPOHP:0033247
- Frequent (30% to 79% of cases)
- Renal insufficiency
Where it sits
- A kind of
Other names
2 names
Resolves to: ALECT2 amyloidosis
- Also called
- LECT2 amyloidosisleukocyte chemotactic factor-2 amyloidosis