AL amyloidosis
Findings
No curated finding names AL amyloidosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.
Definition from the Mondo Disease Ontology (MONDO:0019438), read 2026-09-29. CC BY 4.0.
Features
64 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Congestive heart failureHPOHP:0001635
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Abnormal atrioventricular conductionHPOHP:0005150
- Frequent (30% to 79% of cases)
- Abnormal EKGHPOHP:0003115
- Frequent (30% to 79% of cases)
- Abnormal pulmonary interstitial morphologyHPOHP:0006530
- Frequent (30% to 79% of cases)
- Abnormality of taste sensationHPOHP:0000223
- Frequent (30% to 79% of cases)
- Albuminuria
Reported absent (1)
- Reduced left ventricular ejection fractionHPOHP:0012664
Show the remaining 52
- Hypertrophic cardiomyopathyHPOHP:0001639
- Frequent (30% to 79% of cases)
- Increased circulating immunoglobulin concentrationHPOHP:0010702
- Frequent (30% to 79% of cases)
- Increased circulating troponin I concentrationHPOHP:0410173
- Frequent (30% to 79% of cases)
- Increased circulating troponin T concentrationHPOHP:0410174
- Frequent (30% to 79% of cases)
- Left ventricular hypertrophyHPOHP:0001712
- Frequent (30% to 79% of cases)
- MalabsorptionHPOHP:0002024
Where it sits
Other names
2 names
Resolves to: AL amyloidosis
- Also called
- Light-chain amyloidosisprimary amyloidosis