aggressive systemic mastocytosis
MONDO:0020333Mondo
Findings
No curated finding names aggressive systemic mastocytosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Aggressive systemic mastocytosis (ASM) is a severe and rare form of systemic mastocytosis (SM) characterized by considerable infiltration of mast cells in different tissues.
Definition from the Mondo Disease Ontology (MONDO:0020333), read 2026-09-29. CC BY 4.0.
Features
39 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal mast cell morphologyHPOHP:0100494
- Very frequent (80% to 99% of cases)
- Abdominal crampsHPOHP:0032155
- Frequent (30% to 79% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Anaphylactic shockHPOHP:0100845
- Frequent (30% to 79% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- Bone painHPOHP:0002653
- Frequent (30% to 79% of cases)
- Constitutional symptomHPOHP:0025142
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Frequent (30% to 79% of cases)
- Elevated total serum tryptaseHPOHP:0031901
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
Show the remaining 27
- FlushingHPOHP:0031284
- Frequent (30% to 79% of cases)
- HepatosplenomegalyHPOHP:0001433
- Frequent (30% to 79% of cases)
- HypotensionHPOHP:0002615
- Frequent (30% to 79% of cases)
- Increased CD25+ mast cell proportionHPOHP:0031408
- Frequent (30% to 79% of cases)
- Increased total leukocyte countHPOHP:0001974
- Frequent (30% to 79% of cases)
- LymphadenopathyHPOHP:0002716
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
- Narrower terms (1)
Other names
2 names
Resolves to: aggressive systemic mastocytosis
- Also called
- aggressive systemic mastocytosis (morphologic abnormality)ASM