African iron overload
MONDO:0011012Mondo
Findings
No curated finding names African iron overload yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
African iron overload is a rare disorder described in sub-Saharan African populations and is characterized by iron overload due to excess dietary iron intake and possibly genetic factors, leading to hepatic portal fibrosis and micronodular cirrhosis.
Definition from the Mondo Disease Ontology (MONDO:0011012), read 2026-09-29. CC BY 4.0.
Features
25 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Increased circulating ferritin concentrationHPOHP:0003281
- Very frequent (80% to 99% of cases)
- Elevated hepatic iron concentrationHPOHP:0012465
- Frequent (30% to 79% of cases)
- Elevated transferrin saturationHPOHP:0012463
- Frequent (30% to 79% of cases)
- Hepatic fibrosisHPOHP:0001395
- Frequent (30% to 79% of cases)
- Hepatic periportal necrosisHPOHP:0002614
- Frequent (30% to 79% of cases)
- HepatitisHPOHP:0012115
- Frequent (30% to 79% of cases)
- Viral hepatitisHPOHP:0006562
- Frequent (30% to 79% of cases)
- Abnormal adrenal morphologyHPOHP:0011732
- Occasional (5% to 29% of cases)
- Abnormal heart morphologyHPOHP:0001627
- Occasional (5% to 29% of cases)
- Abnormal pancreas morphologyHPOHP:0012090
- Occasional (5% to 29% of cases)
- Abnormal thyroid morphologyHPOHP:0011772
- Occasional (5% to 29% of cases)
- Abnormality of the genital systemHPOHP:0000078
- Occasional (5% to 29% of cases)
Show the remaining 13
- Chronic infectionHPOHP:0031035
- Occasional (5% to 29% of cases)
- Congestive heart failureHPOHP:0001635
- Occasional (5% to 29% of cases)
- Decreased circulating vitamin C concentrationHPOHP:0100510
- Occasional (5% to 29% of cases)
- Diabetes mellitusHPOHP:0000819
- Occasional (5% to 29% of cases)
- Hepatic bridging fibrosisHPOHP:0012852
- Occasional (5% to 29% of cases)
- Hepatic steatosisHPOHP:0001397
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: African iron overload
- Also called
- Bantu siderosis