adult-onset Still disease
MONDO:0019355Mondo
Findings
No curated finding names adult-onset Still disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Definition from the Mondo Disease Ontology (MONDO:0019355), read 2026-09-29. CC BY 4.0.
Features
56 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Arthralgia/arthritisHPOHP:0005059
- Very frequent (80% to 99% of cases)
- ArthritisHPOHP:0001369
- Very frequent (80% to 99% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Very frequent (80% to 99% of cases)
- Elevated erythrocyte sedimentation rateHPOHP:0003565
- Very frequent (80% to 99% of cases)
- ErythemaHPOHP:0010783
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- Increased circulating ferritin concentrationHPOHP:0003281
- Very frequent (80% to 99% of cases)
- Increased total leukocyte countHPOHP:0001974
- Very frequent (80% to 99% of cases)
- Increased total neutrophil countHPOHP:0011897
- Very frequent (80% to 99% of cases)
- Joint swellingHPOHP:0001386
- Very frequent (80% to 99% of cases)
Reported absent (3)
- LymphomaHPOHP:0002665
- SepsisHPOHP:0100806
- Severe Epstein Barr virus infectionHPOHP:0031693
Show the remaining 44
- PruritusHPOHP:0000989
- Very frequent (80% to 99% of cases)
- Skin rashHPOHP:0000988
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- AstheniaHPOHP:0025406
- Frequent (30% to 79% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Frequent (30% to 79% of cases)
Where it sits
Other names
3 names
Resolves to: adult-onset Still disease
- Also called
- Adult-Onset Still's DiseaseAOSDWissler-Fanconi syndrome