adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia
Findings
No curated finding names adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Diazoxide-resistant hyperinsulism (DRH) is form of congenital isolated hyperinsulinism caused by an abnormal insulin production by b-cells in the pancreas that can be diffuse or focal and is characterized by an excessive/ uncontrolled insulin secretion (inappropriate for the level of glycemia), recurrent episodes of profound hypoglycemia and resistance to medical management with diazoxide
Definition from the Mondo Disease Ontology (MONDO:0017189), read 2026-09-29. CC BY 4.0.
Features
21 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ComaHPOHP:0001259
- Very frequent (80% to 99% of cases)
- Fasting hypoglycemiaHPOHP:0003162
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Generalized muscle weaknessHPOHP:0003324
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- Hyperinsulinemic hypoglycemiaHPOHP:0000825
- Very frequent (80% to 99% of cases)
- Hypoketotic hypoglycemia
Show the remaining 9
- TachycardiaHPOHP:0001649
- Very frequent (80% to 99% of cases)
- TremorHPOHP:0001337
- Very frequent (80% to 99% of cases)
- HyperinsulinemiaHPOHP:0000842
- Frequent (30% to 79% of cases)
- Reactive hypoglycemiaHPOHP:0012051
- Frequent (30% to 79% of cases)
- AgitationHPOHP:0000713
- Occasional (5% to 29% of cases)
- DrowsinessHPOHP:0002329
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia
- Also called
- NI-PHH