adrenal cortex carcinoma
Findings
No curated finding names adrenal cortex carcinoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells. Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women. Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes. Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.
Definition from the Mondo Disease Ontology (MONDO:0006639), read 2026-09-29. CC BY 4.0.
Features
29 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Adrenocortical carcinomaHPOHP:0006744
- Obligate (100% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormal circulating dehydroepiandrosterone concentrationHPOHP:0500022
- Frequent (30% to 79% of cases)
- Abnormality of metabolism/homeostasisHPOHP:0001939
- Frequent (30% to 79% of cases)
- Abnormality of reproductive system physiologyHPOHP:0000080
- Frequent (30% to 79% of cases)
- Adrenocorticotropic hormone deficiencyHPOHP:0011748
- Frequent (30% to 79% of cases)
Show the remaining 17
- HypokalemiaHPOHP:0002900
- Frequent (30% to 79% of cases)
- Increased body weightHPOHP:0004324
- Frequent (30% to 79% of cases)
- Increased circulating aldosterone concentrationHPOHP:0000859
- Frequent (30% to 79% of cases)
- Increased circulating androgen concentrationHPOHP:0030348
- Frequent (30% to 79% of cases)
- Increased circulating androstenedione concentrationHPOHP:0025380
- Frequent (30% to 79% of cases)
- Increased circulating cortisol levelHPOHP:0003118
Where it sits
- Narrower terms (1)
Other names
12 names
Resolves to: adrenal cortex carcinoma
- Also called
- ACCadenocarcinoma, adrenocortical, malignantadrenal cortex adenocarcinomaadrenal cortical adenocarcinomaadrenal cortical carcinomaadrenal cortical carcinoma (morphologic abnormality)adrenocortical carcinomaadrenocortical carcinoma (disease)carcinoma of adrenal cortexcarcinoma of the adrenal cortexcarcinoma, adrenocortical, malignantcortical cell carcinoma