acute promyelocytic leukemia
Findings
No curated finding names acute promyelocytic leukemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue.
Definition from the Mondo Disease Ontology (MONDO:0012883), read 2026-09-29. CC BY 4.0.
- Inheritance
- Typified by somatic mosaicism
HPO, annotations 2026-09-02
Features
36 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal bleedingHPOHP:0001892
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- Bone marrow hypercellularityHPOHP:0031020
- Frequent (30% to 79% of cases)
- Bruising susceptibilityHPOHP:0000978
- Frequent (30% to 79% of cases)
- Chronic infectionHPOHP:0031035
- Frequent (30% to 79% of cases)
- Decreased total leukocyte countHPO
Show the remaining 24
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- Gingival bleedingHPOHP:0000225
- Frequent (30% to 79% of cases)
- Muscle weaknessHPOHP:0001324
- Frequent (30% to 79% of cases)
- PancytopeniaHPOHP:0001876
- Frequent (30% to 79% of cases)
- PetechiaeHPOHP:0000967
- Frequent (30% to 79% of cases)
- PurpuraHPOHP:0000979
- Frequent (30% to 79% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- RARAHGNC:9864
- No Known Disease Relationship · Ambry Genetics · Autosomal dominant · 2018
Where it sits
- A kind of
Other names
21 names
Resolves to: acute promyelocytic leukemia
- Also called
- acute myeloblastic leukaemia 3acute myeloblastic leukemia 3acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variantsacute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variantsacute promyelocytic leukaemia with PML-raraacute promyelocytic leukaemia with t(15;17)(q22;q12); PML-raraacute promyelocytic leukaemia with t(15;17)(q22;q12); PML/raraacute promyelocytic leukemia with PML-raraacute promyelocytic leukemia with t(15;17)(q22;q12); PML-raraacute promyelocytic leukemia with t(15;17)(q22;q12); PML/raraAML M3AML with t(15;17)(q22;q12)AML with t(15;17)(q22;q12);(PML/RARalpha) and variantsAPL