acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
Findings
No curated finding names acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent is a subgroup of therapy-related myeloid neoplasms (t-MN), associated with a treatment of an unrelated neoplastic or autoimmune disease with cytotoxic agents, like cyclophosphamid, platins, melphalan and others. The neoplastic cells typically harbor unbalanced aberrations of chromosomes 5 and 7 (monosomy 5/del(5q) and monosomy 7/del(7q)) or a complex karyotype. It usually presents with multilineage dysplasia and cytopenias 5-10 years after exposure, with symptoms related to the degree of bone marrow failure and the corresponding cytopenia (fatigue, bleeding and bruising, recurrent infections, bone pain).
Definition from the Mondo Disease Ontology (MONDO:0015164), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
1 name
Resolves to: acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent
- Also called
- AML and myelodysplastic syndromes related to alkylating agent