acute megakaryoblastic leukemia
Findings
No curated finding names acute megakaryoblastic leukemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.
Definition from the Mondo Disease Ontology (MONDO:0018872), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
15 names
Resolves to: acute megakaryoblastic leukemia
- Also called
- acute M7 myeloid leukaemiaacute M7 myeloid leukemiaacute megakaryoblastic leukaemia (FAB type M7)acute megakaryoblastic leukemia (FAB type M7)acute megakaryoblastic leukemia, FAB M7acute megakaryocytic leukaemiaacute megakaryocytic leukemiaacute megakaryocytic leukemiasacute myeloid leukaemia M7acute myeloid leukemia M7AMKLAML M7FAB M7leukemia, megakaryocytic, malignantthrombocytic leukemia