acute liver failure
MONDO:0019542Mondo
Findings
No curated finding names acute liver failure yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Rapid deterioration of liver function causing encephalopathy and coagulopathy. It results from damage to the liver parenchyma usually secondary to acetaminophen overdose or viral infections.
Definition from the Mondo Disease Ontology (MONDO:0019542), read 2026-09-29. CC BY 4.0.
Features
50 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Elevated circulating hepatic transaminase concentrationHPOHP:0002910
- Very frequent (80% to 99% of cases)
- HepatitisHPOHP:0012115
- Very frequent (80% to 99% of cases)
- Hepatocellular necrosisHPOHP:0001404
- Very frequent (80% to 99% of cases)
- JaundiceHPOHP:0000952
- Very frequent (80% to 99% of cases)
- Abnormal pattern of respirationHPOHP:0002793
- Frequent (30% to 79% of cases)
- Abnormal respiratory system physiologyHPOHP:0002795
- Frequent (30% to 79% of cases)
- Abnormality of the coagulation cascadeHPOHP:0003256
- Frequent (30% to 79% of cases)
- Adrenal insufficiencyHPOHP:0000846
- Frequent (30% to 79% of cases)
- AgitationHPOHP:0000713
- Frequent (30% to 79% of cases)
- Bruising susceptibilityHPOHP:0000978
- Frequent (30% to 79% of cases)
- ConfusionHPOHP:0001289
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
Show the remaining 38
- DrowsinessHPOHP:0002329
- Frequent (30% to 79% of cases)
- Emotional labilityHPOHP:0000712
- Frequent (30% to 79% of cases)
- Hepatic necrosisHPOHP:0002605
- Frequent (30% to 79% of cases)
- Hepatic periportal necrosisHPOHP:0002614
- Frequent (30% to 79% of cases)
- HyperammonemiaHPOHP:0001987
- Frequent (30% to 79% of cases)
- HypoglycemiaHPOHP:0001943
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: acute liver failure
- Also called
- acute hepatic failurefulminant hepatic failure