acute adrenal insufficiency
MONDO:0019801Mondo
Findings
No curated finding names acute adrenal insufficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A primary adrenal insufficiency caused by a sudden defective production of adrenal steroids (cortisol and aldosterone). It represents an emergency, thus the rapid recognition and prompt therapy are critical for survival even before the diagnosis is made.
Definition from the Mondo Disease Ontology (MONDO:0019801), read 2026-09-29. CC BY 4.0.
Features
44 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased circulating cortisol levelHPOHP:0008163
- Obligate (100% of cases)
- Primary adrenal insufficiencyHPOHP:0008207
- Obligate (100% of cases)
- Abdominal painHPOHP:0002027
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Very frequent (80% to 99% of cases)
- AutoimmunityHPOHP:0002960
- Very frequent (80% to 99% of cases)
- ConstipationHPOHP:0002019
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Very frequent (80% to 99% of cases)
- Failure to thriveHPOHP:0001508
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Hyperpigmentation of the skinHPOHP:0000953
- Very frequent (80% to 99% of cases)
- HypotensionHPOHP:0002615
- Very frequent (80% to 99% of cases)
- HypovolemiaHPOHP:0011106
- Very frequent (80% to 99% of cases)
Show the remaining 32
- Increased circulating ACTH levelHPOHP:0003154
- Very frequent (80% to 99% of cases)
- Muscle weaknessHPOHP:0001324
- Very frequent (80% to 99% of cases)
- Nausea and vomitingHPOHP:0002017
- Very frequent (80% to 99% of cases)
- Weight lossHPOHP:0001824
- Very frequent (80% to 99% of cases)
- Androgen insufficiencyHPOHP:0008226
- Frequent (30% to 79% of cases)
- Decreased circulating aldosterone concentrationHPOHP:0004319
Where it sits
- Narrower terms (2)
Other names
5 names
Resolves to: acute adrenal insufficiency
- Also called
- acute adrenal failureacute adrenocortical insufficiencyAddisonian crisisadrenal crisisadrenocortical crisis