acromegaly
Findings
No curated finding names acromegaly yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations.
Definition from the Mondo Disease Ontology (MONDO:0019933), read 2026-09-29. CC BY 4.0.
Features
93 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of the endocrine systemHPOHP:0000818
- Very frequent (80% to 99% of cases)
- Acral overgrowthHPOHP:0033794
- Very frequent (80% to 99% of cases)
- Anterior hypopituitarismHPOHP:0000830
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Broad footHPOHP:0001769
- Very frequent (80% to 99% of cases)
- Broad foreheadHPOHP:0000337
- Very frequent (80% to 99% of cases)
- Coarse facial featuresHPOHP:0000280
- Very frequent (80% to 99% of cases)
- Cortical diaphyseal thickening of the upper limbsHPOHP:0003859
- Very frequent (80% to 99% of cases)
- Deep palmar creaseHPOHP:0006191
- Very frequent (80% to 99% of cases)
- Deep plantar creasesHPOHP:0001869
- Very frequent (80% to 99% of cases)
- Elevated circulating growth hormone concentrationHPOHP:0000845
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
Show the remaining 81
- Full cheeksHPOHP:0000293
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- Joint swellingHPOHP:0001386
- Very frequent (80% to 99% of cases)
- Large handsHPOHP:0001176
- Very frequent (80% to 99% of cases)
- Long faceHPOHP:0000276
- Very frequent (80% to 99% of cases)
- MacrodactylyHPOHP:0004099
- Very frequent (80% to 99% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- A kind of