acral peeling skin syndrome
Findings
No curated finding names acral peeling skin syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acral peeling skin syndrome (PSS) is a form of PSS characterized by superficial peeling of the skin predominantly affecting the dorsa of the hands and feet.
Definition from the Mondo Disease Ontology (MONDO:0012345), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
HPO, annotations 2026-09-02
Features
14 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Cleavage at junction of stratum corneum and stratum granulosumHPOHP:0034838
- 1 of 1 reported patient
- ErythemaHPOHP:0010783
- 6 of 6 reported patients
- Frequent (30% to 79% of cases)
- Scaling skinHPOHP:0040189
- 6 of 6 reported patients
- Frequent (30% to 79% of cases)
- Abnormal blistering of the skinHPOHP:0008066
- Frequent (30% to 79% of cases)
- AllergyHPOHP:0012393
- Frequent (30% to 79% of cases)
- Eczematoid dermatitisHPOHP:0000964
- Frequent (30% to 79% of cases)
Show the remaining 2
- Skin erosionHPOHP:0200041
- Occasional (5% to 29% of cases)
- Abnormal nail morphologyHPOHP:0001597
- 0 of 6 reported patients
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TGM5HGNC:11781
- Definitive · G2P · Autosomal recessive · 2019
- Strong · Genomics England PanelApp · Autosomal recessive · 2020
- Strong · Genomics England PanelApp · Autosomal recessive · 2020
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2018
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Supportive · Orphanet · Autosomal recessive · 2021
- CSTAHGNC:2481
- Supportive · Orphanet · Autosomal recessive · 2021
Where it sits
- A kind of
Other names
7 names
Resolves to: acral peeling skin syndrome
- Also called
- acral deciduous skinacral PSSlocalised deciduous skinlocalised PSSlocalized deciduous skinlocalized PSSpeeling skin syndrome type 2