acquired von willebrand syndrome
Findings
No curated finding names acquired von willebrand syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Acquired von Willebrand syndrome (AVWS) is a bleeding disorder marked by the same biological anomalies as those seen in hereditary von Willebrand disease (VWD) but which occurs in association with another underlying pathology, generally in elderly patients without any personal or family history of bleeding anomalies.
Definition from the Mondo Disease Ontology (MONDO:0020460), read 2026-09-29. CC BY 4.0.
Features
27 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Frequent (30% to 79% of cases)
- Hematological neoplasmHPOHP:0004377
- Frequent (30% to 79% of cases)
- Impaired ristocetin cofactor assay activityHPOHP:0030129
- Frequent (30% to 79% of cases)
- Prolonged prothrombin timeHPOHP:0008151
- Frequent (30% to 79% of cases)
- Reduced factor VIII activityHPOHP:0003125
- Frequent (30% to 79% of cases)
- Reduced von Willebrand factor activityHPOHP:0008330
- Frequent (30% to 79% of cases)
- Aortic regurgitationHPOHP:0001659
- Occasional (5% to 29% of cases)
- Aortic valve stenosisHPOHP:0001650
- Occasional (5% to 29% of cases)
- AstheniaHPOHP:0025406
- Occasional (5% to 29% of cases)
- Bruising susceptibilityHPOHP:0000978
- Occasional (5% to 29% of cases)
- EpistaxisHPOHP:0000421
- Occasional (5% to 29% of cases)
- Gastrointestinal angiodysplasiaHPOHP:0000471
- Occasional (5% to 29% of cases)
Show the remaining 15
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
- HematuriaHPOHP:0000790
- Occasional (5% to 29% of cases)
- Hypochromic anemiaHPOHP:0001931
- Occasional (5% to 29% of cases)
- HypotensionHPOHP:0002615
- Occasional (5% to 29% of cases)
- Joint hemorrhageHPOHP:0005261
- Occasional (5% to 29% of cases)
- MelenaHPOHP:0002249
- Occasional (5% to 29% of cases)
Where it sits
Other names
2 names
Resolves to: acquired von willebrand syndrome
- Also called
- acquired von Willebrand diseaseacquired von Willebrand disease (hereditary or acquired)